The Scream 2022 cast features Neve Campbell, Courteney Cox and David Arquette. This info article contains minor spoilers and character dertails for Matt Bettinelli-Olpin and Tyler Gillett’s 2022 movie. Check out more streaming guides in Vague Visages’ Know the Cast section.

Scream 2022 takes place 25 years after the original franchise film. A new Ghostface emerges and terrorizes the residents of Woodsboro. When a young woman from Modesto arrives to investigate, she reveals a big secret about her familial lineage, thus prompting various teenagers to gossip about her motivations. Here’s every main player in Scream 2022.

Read More at VV — Know the Cast: ‘Fresh’

Scream 2022 Cast: Neve Campbell as Sidney Prescott

Character Profile: The main protagonist of the Scream franchise. She learns about the new Ghostface from a retired sheriff, Dewey, and arrives in Woodsboro to help. Sidney initially clashes with a character named Sam and urges her not to flee.

Campbell’s Resume: Julia Salinger in Party of Five (1994-2000), Sidney Prescott in the Scream Movie Franchise (1996-), Suzie Toller in Wild Things (1998), Leann Harvey in House of Cards (2016-17), Laura Sobiech in Clouds (2020)

Read More at VV — Know the Cast: ‘Death on the Nile’

Scream 2022 Cast: Courteney Cox as Gale Weathers

Character Profile: Sidney’s long-time friend, a journalist. She lives in New York City after breaking up with the aforementioned Dewey. Gale teams up with Sidney while sorting through personal issues.

Cox’s Resume: Monica Geller in Friends (1994-2004), Gale Weathers in the Scream Movie Franchise (1996-), Cybil Waingrow in 3000 Miles to Graceland (2001), Lucy Spiller in Dirt (2007-08), Jules Cobb in Cougar Town (2009-15)

Read More at VV — Know the Cast: ‘The Bubble’

Scream 2022 Cast: David Arquette as Dewey Riley

Character Profile: A retired Woodsboro sheriff. He receives a visit from a victim’s sister and agrees to help investigate the new Ghostface. Dewey reunites with Gale after previously abandoning her in New York City.

Arquette’s Resume: Keith “Two-Bit” Mathews in The Outsiders (1990), Dewey Riley in the Scream Movie Franchise (1996-), Rob Geller in Never Been Kissed (1999), Frank Barnes in Cleaners (2013-14), Himself in You Cannot Kill David Arquette (2020)

Read More at VV — Know the Cast: ‘All Hail’

Scream 2022 Cast: Melissa Barrera as Sam Carpenter

Character Profile: The primary protagonist from Modesto, California. She arrives in Woodsboro after her sister is attacked. Sam theorizes about Ghostface’s identity with her boyfriend.

Barrera’s Resume: Isabel Cantú in Club de Cuervos (2017), Daniela in Dos Veces Tú (2018), Lyn in Vida (2018-20), Chama in All the World Is Sleeping (2021), Vanessa in In the Heights (2021)

Read More at VV — Know the Cast: ‘Moonshot’

Scream 2022 Cast: Jack Quaid as Richie Kirsch

Character Profile: Sam’s boyfriend from Modesto. He tries to avoid danger but ends becoming a key figure in the Ghostface mystery. Richie provides comic relief throughout the movie.

Quaid’s Resume: Marvel in The Hunger Games Movie Franchise (2012-13), Clark Morelle in Vinyl (2016), Fish Bang in Logan Lucky (2017), Hughie Campbell in The Boys (2019-), Ensign Brad Boimler in Star Trek: Lower Decks (2020-)

Read More at VV — Know the Cast: ‘Belfast’

Scream 2022 Cast: Mikey Madison as Amber Freeman

Character Profile: A Woodsboro teenager. She observes classmates as they react to the new Ghostface killer. Amber listens closely to theories from her friend Mindy.

Madison’s Resume: Max in Better Things (2016-), Alexandra Floyd in Monster (2018),  Sadie in Once Upon a Time in Hollywood (2019), Candi the Barista in The Addams Family (2019), Kat Walker in It Takes Three (2021)

Read More at VV — Know the Cast: ‘CODA’

Scream 2022 Cast: Jenna Ortega as Tara Carpenter

Character Profile: Sam’s sister. She survives an attack in the opening sequence. Tara appreciates The Babadook and spends most of the film recovering from her injuries.

Ortega’s Resume: Vice President’s Daughter in Iron Man 3 (2013), Stuck in the Middle in Stuck in the Middle (2016-18), Princess Isabel in Elena of Avalor (2016-20), Phoebe in The Babysitter: Killer Queen (2020), Vada Cavell in The Fallout (2022)

Read More at VV — Know the Cast: ‘In Good Hands’

Scream 2022 Cast: Dylan Minnette as Wes Hicks

Character Profile: Tara’s classmate, the son of franchise character Judy Hicks. He informs Sam about the Ghostface attack in Woodsboro. Wes encounters the killer at his home.

Minnette’s Resume: Kenny in Let Me In (2010), Ralph Dover in Prisoners (2013), Anthony Cooper in Alexander and the Terrible, Horrible, No Good, Very Bad Day (2014), Zach in Goosebumps (2015), Clay Jensen in 13 Reasons Why (2017-20)

Read More at VV — Know the Cast: ‘Rescued by Ruby’

Scream 2022 Cast: Jasmin Savoy Brown as Mindy Meeks-Martin

Character Profile: Tara’s classmate. She believes that the killer is making a “requel” version of “Stab 8.” Mindy is the niece of franchise character Randy Meeks.

Brown’s Resume: Evangeline Murphy in The Leftovers (2015-17), Emilia Bassano in Will (2017), Allison Adams in For the People (2018-19), Annie in Love (2018), Alexis Reeves in Sound of Violence (2021), Young Taissa Turner in Yellowjackets (2021-)

Read More at VV — Know the Cast: ‘Marilyn’s Eyes’

Scream 2022 Cast: Mason Gooding as Chad Meeks-Martin

Character Profile: Mindy’s twin brother. He’s the archetypal Confident Jock character who jokes about avoiding “the looming specter of death.” Chad clashes with his girlfriend Liv because he views her as a logical suspect.

Gooding’s Resume: Parker Jones in Ballers (2018), Jeb in Let It Snow (2019), Nick in Booksmart (2019), Andrew in Love, Victor (2020-), Luke in Everything’s Gonna Be Okay (2020)

Read More at VV — Know the Cast: ‘Black Crab’

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The Scream 2022 cast also includes Sonia Ammar (Jappeloup), Marley Shelton (Never Been Kissed, Scream 4), Skeet Ulrich (Scream, Riverdale), Kyle Gallner (American Sniper, Dinner in America), Chester Tam (Hot Rod Workaholics), Heather Matarazzo (Welcome to the Dollhouse, Scream 3) and Roger Jackson (The Voice in the Scream franchise).

Q.V. Hough (@QVHough) is Vague Visages’ founding editor.