Know the Cast: ‘Malignant’

Malignant Cast - Every Main Performer and Character in the 2021 Movie

The Malignant cast features Annabelle Wallis, Maddie Hasson and Marina Mazepa. This info article contains minor spoilers for James Wan’s 2021 movie. Check out Vague Visages’ Know the Cast section for more streaming guides.

Malignant follows a Seattle woman named Madison Mitchell. She experiences physical abuse and three miscarriages, which seems to explain her psychological trauma. When Maddie begins communicating with a creature known as Gabriel, family members uncover disturbing information about her childhood at Simion Research Hospital. Here’s every main character and performer in Malignant.

Malignant Cast: Annabelle Wallis as Madison Mitchell

Malignant Cast - Annabelle Wallis as Madison Mitchell

Character Profile: A Seattle woman who experiences night terrors and seemingly watches various murders happen in real-time. Madison learns that she used to have an imaginary friend named Gabriel, and that she was the primary subject in a case study about children with teratomas.

Wallis’ Resume: Jane Seymour in The Tudors (2009-10), Grace Burgess in Peaky Blinders (2013-19), Jenny Halsey in The Mummy (2017), Mia Form in Annabelle: Creation (2017), Rebecca Crosby in Tag (2018)

Malignant Cast: Maddie Hasson as Sydney Lake

Malignant Cast - Maddie Hasson as Sydney Lake

Character Profile: Maddie’s sister. She performs as a princess at Family Planet. Maddie flirts with detective George Young, and ultimately makes a breakthrough in her sister’s case upon visiting the abandoned Simion Research Hospital.

Hasson’s Resume: Willa Monday in The Finder (2012), Jo Masterson in Twisted (2013-14), Billie Jean Jones in I Saw the Light (2015), Allie Hodges in Mr. Mercedes (2017-19), Henrietta “Henry” Coles in Impulse (2018-19)

Malignant Cast: George Young as Kekoa Shaw

Malignant Cast - George Young as Kekoa Shaw

Character Profile: A Seattle detective. He investigates Maddie’s childhood and learns that she used to be known as Emily May. Kekoa has a physical confrontation with the primary villain, Gabriel.

Young’s Resume: Benjamin Wong in The Pupil (2011), James in Yours Fatefully (2012), Charles in Grace (2014), Victor Cannerts in Containment (2016), Ray in A Bread Factory (2018)

Malignant Cast: Michole Briana White as Regina Moss

Malignant Cast - Michole Briana White as Regina Moss

Character Profile: A Seattle detective and Kokoa’s colleague. She believes from the start that Maddie killed her husband, and becomes even more convinced when she discovers “Jeffrey Dahmer’s workshop” in the attic. Regina changes her mind when Gabriel makes a phone call during an interrogation scene.

White’s Resume: Kathleen in Encino Man (1992), Maria in Courage Under Fire (1996), Karen in The Parent ‘Hood (1996-97), Nadiyah in She Hate Me (2004), Simone Winters in Reed Between the Lines (2015)

Malignant Cast: Jean Louisa Kelly as Serena May

Malignant Cast - Jean Louisa Kelly as Serena May

Character Profile: Maddie’s birth mother. She was sexually assaulted at age 15 and allowed doctors to conduct experiments on her daughter. Serena works as a tour guide at The Seattle Underground.

Kelly’s Resume: Tia Russell in Uncle Buck (1989), Rowena Morgan in Mr. Holland’s Opus (1995), Kim Warner in Yes, Dear (2000-06), Pastor Nicole in The Fosters (2018), Katie Miller in The Call of the Wild (2020)

Malignant Cast: Susanna Thompson as Jeanne

Malignant Cast - Susanna Thompson as Jeanne

Character Profile: Maddie’s adoptive mother. She reveals that Wallis’ character used to have an imaginary friend named Gabriel. Jeanne isn’t initially sure what happened to Maddie at Simion Research Hospital but finds out thanks to her daughter Sydney’s research.

Thompson’s Resume: Peggy Lloyd in Ghosts of Mississippi (1996), Karen Sammler in Once and Again (1999-2002), Borg Queen in Star Trek: Voyager (1999-2000), Emily Darrow in Dragonfly (2002), Moira Queen in Arrow (2012-20)

Malignant Cast: Jake Abel as Derek Mitchell

Malignant Cast - Jake Abel as Derek Mitchell

Character Profile: Maddie’s abusive husband. He awakens something inside his wife after attacking her. Derek is the first murder victim in Malignant.

Abel’s Resume: Michael/Adam Milligan in Supernatural (2009-20), Luke in the Percy Jackson Movie Franchise (2010-), Ian O’Shea in The Host (2013), Mike Love in Love & Mercy (2014), Sasha Harrison in Another Life (2019)

Malignant Cast: Jacqueline McKenzie as Florence Weaver

Malignant Cast - Jacqueline McKenzie as Florence Weaver

Character Profile: A specialist in child reconstructive surgery. She performed tests on Maddie/Emily in 1993 at Simion Research Hospital. Dr. Weaver is one of several doctors that Gabriel targets.

McKenzie’s Resume: Gabe in Romper Stomper (1992), Janice Higgins in Deep Blue Sea (1999), Veronica Hayden-Jones in Mental (20090,  Eliza in The Water Diviner (2014), Anne Carter in Bloom (2020)

Malignant Cast: Mckenna Grace as Young Madison Mitchell

Malignant Cast - Mckenna Grace as Young Madison Mitchell

Character Profile: A patient at Simion Research Hospital. She speaks with an imaginary friend named Gabriel after being adopted. Young Madison communicates with her pal through a telephone, and she’s urged to harm family members.

Grace’s Resume: Penny Kirkman in Designated Survivor (2016-19), Paige Swanson in Young Sheldon (2018-), Young Theo in The Haunting of Hill House (2018), Young Carol in Captain Marvel (2019), Esther Keyes in The Handmaid’s Tale (2021)

Malignant Cast: Marina Mazepa as Gabriel

Malignant Cast - Marina Mazepa as Gabriel

Character Profile: The primary villain. Gabriel initially appears to be a supernatural creature with extraordinary athletic skills. The character is revealed to be an extreme version of Maddie’s teratoma, which was originally repressed into her brain as a child. Gabriel feeds on Maddie’s body and reawakens after Derek’s first act attack.

Mazepa’s Resume: Herself in America’s Got Talent (2019), Fabianna in Savage/Love (2020), Mary of Elnor in The Unholy (2021), Lisa Trevor in Resident Evil: Welcome to Raccoon City (2021)


The Malignant cast also includes Christian Clemenson (Apollo 13, The Big Lebowski), Amir Aboulela (Curb Your Enthusiasm, Why Women Kill), Mercedes Colon (JAG, The Fosters), Ingrid Bisu (Toni Erdmann, The Conjuring: The Devil Made Me Do It) and Zoe Bell (Death Proof, Once Upon a Time in Hollywood).

Q.V. Hough (@QVHough) is Vague Visages’ founding editor.

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