The Pain Hustlers cast features Emily Blunt, Chris Evans and Catherine O’Hara. This info article contains minor spoilers and cast/character summaries for David Yates’ 2023 Netflix movie. Check out more streaming guides in Vague Visages’ Know the Cast category, and then browse complete soundtrack song listings in the Soundtracks of Cinema section.

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Pain Hustlers centers on a single mother who works for a pharmaceutical company. When Liza Drake receives a potentially life-changing opportunity, she becomes a central figure in a medical conspiracy. The narrative follows the main protagonist as she reaches an epiphany about the bigger picture. Here’s every actor and character in Pain Hustlers, an adaptation of Evan Hughes’ 2022 book.

Read More at VV — Know the Cast: ‘Old Dads’

Pain Hustlers Cast: Emily Blunt as Liza Drake

Character Profile: The vice president of marketing for  Zanna Therapeutics. She is a single mother who used to work as an exotic dancer while selling TCH gummies. Liza develops speaker and bribery programs for her employer.

Blunt’s Resume: Emily in The Devil Wears Prada (2006), Elise Sellas in The Adjustment Bureau (2011), Rita in Edge of Tomorrow (2014), Evelyn Abbott in A Quiet Place (2018), Kitty Oppenheimer in Oppenheimer (2023)

Read More at VV — Know the Cast: ‘Neon’

Pain Hustlers Cast: Chris Evans as Pete Brenner

Character Profile: The CEO of Zanna Therapeutics. He is a Boston native with unresolved parental issues. Pete is a greedy man who hires Liza.

Evans’ Resume: Johnny Storm in Fantastic Four (2005), Lucas Lee in Scott Pilgrim vs. the World (2010), Steve Rogers/Captain America in the MCU (2011-), Curtis in Snowpiercer (2013), Ransom Drysdale in Knives Out (2019)

Read More at VV — Know the Cast: ‘Bodies’

Pain Hustlers Cast: Catherine O’Hara as Jackie

Character Profile: Liza’s mother. She is a hippie who has been married four times. Jackie receives a job at Zanna Therapeutics and hooks up with her boss.

O’Hara’s Resume: Kate in Home Alone (1990), Cookie Fleck in Best in Show (2000), Mickey Crabbe in A Mighty Wind (2003), Mrs. Frankenstein in Frankenweenie (2012), Moira Rose in Schitt’s Creek (2015-20)

Read More at VV — Know the Cast: ‘The Conference’

Pain Hustlers Cast: Andy García as Dr. Neel

Character Profile: The head of Zanna Therapeutics. He is a billionaire widower who develops a pill called Lonafen. Dr. Peel targets the “poor, hungry and dumb.”

García’s Resume: Angel Maldonado in 8 Million Ways to Die (1986), Vincent Mancini in The Godfather: Part III (1990), Sean Casey in Night Falls on Manhattan (1996), Terry Benedict in Ocean’s Eleven (2001), Billy in Father of the Bride (2022)

Read More at VV — Know the Cast: ‘The Fall of the House of Usher’

Pain Hustlers Cast: Jay Duplass as Larkin

Character Profile: The vice president of marketing for Zanna Therapeutics. He is backstabber who complains about Liza. Larkin gets pushed out his company.

Duplass’ Resume: Duncan Deslaurier in The Mindy Project (2012-17), Josh Pfefferman in Transparent (2014-19), English Teacher in Paper Towns (2015), Alex in Beatriz at Dinner (2017), Elijah in Search Party (2017-20)

Read More at VV — Know the Cast: ‘Ballerina’

Pain Hustlers Cast: Brian d’Arcy James as Dr. Lydell

Character Profile: A German-American doctor at Lakeland Pain Management. He is known as the “nine million dollar man.” Dr. Lydell sells off-label pills to patients.

James’ Resume: Shrek in Shrek the Musical (2013), Matt Carroll in Spotlight (2015), Victor LeConte in Evil (2021-22), Officer Krupke in West Side Story (2021), Bruce in Dear Edward (2023)

Read More at VV — Know the Cast: ‘Fair Play’

The Pain Hustlers cast also includes:

• Amit Shah as Eric Paley
• Chloe Coleman as Phoebe
• Valerie LeBlanc as Laurene
• Aubrey Dollar as Andy
• Alex Klein as Sidney
• Britt Rentschler as Camille
• Michael Kosta as Guy Schatz
• Nick J. McNeil as Randy
• Bella Winkowski as Łuną
• Willie Raysor as Matt

Q.V. Hough (@QVHough) is Vague Visages’ founding editor.