The Little Brother cast features John Cena, Eric André and Michelle Monaghan. This info article contains minor spoilers and character details for Matt Spicer’s 2026 Netflix movie. Check out more cast guides in Vague Visages’ Know the Cast category.

Little Brother takes place in New York City. As a real estate agent develops a reality TV persona, he reunites with a former friend from a mentorship program. The narrative follows the main protagonists as they develop a genuine friendship while resolving issues from the past. Here’s every actor and character in Little Brother.

Read More at VV — Know the Cast: ‘Office Romance’

Little Brother Cast: John Cena as Rudd Landy

Character Profile: A New York City-based real estate agent. He is a married New Jersey native who participates in a reality TV show called “NYC Hustlers.” Rudd tries to impress his older brother while dealing with someone from his past.

Cena’s Resume: A WWE Superstar — Also, Steven in Trainwreck (2015), Agent Burns in Bumblebee (2018), Peacemaker in The Suicide Squad (2021), Will Derringer in Heads of State (2025)

Read More at VV — Know the Cast: ‘Roommates’

Little Brother Cast: Eric André as Marcus Pinchel

Character Profile: Rudd’s estranged friend from a mentorship program. He is a North Carolina native and former foster child who struggles with abandonment issues. Marcus mistakenly believes that he’s been communicating over the years with Rudd via e-mail.

André’s Resume: A Popular Stand-Up Comedian — Also, Chris Carey in Bad Trip (2021), Darius in Sing (2021), Lyle Lissons in The Righteous Gemstones (2022), Eco Warrior Aaron in Balls Up (2026)

Read More at VV — Know the Cast: ‘People We Meet on Vacation’

Little Brother Cast: Michelle Monaghan as Deirdre Landy

Character Profile: Rudd’s wife. She develops a fast friendship with Marcel. Deirdre misses the old version of her husband.

Monaghan’s Resume: Harmony Faith Lane in Kiss Kiss Bang Bang (2005), Angie Gennaro in Gone Baby Gone (2007), Violet in Pixels (2015), Jessica Morgan in The Family Plan (2023), Bonnie Witt in Bad Monkey (2024-)

Read More at VV — Know the Cast: ‘Voicemails for Isabelle’

Little Brother Cast: Christopher Meloni as Josh Landy

Character Profile: Rudd’s older brother. He is a billionaire hedge fund manager. Josh tries to influence his cultural persona while Rudd films a reality TV show.

Meloni’s Resume: Detective Elliot Stabler in Law & Order: Special Victims Unit (1999-2025), Freakshow in Harold & Kumar (2004), Colonel Nathan Hardy in Man on Steel (2013), Mort in Sin City 2: A Dame to Kill For (2014), Roger Simmons in Snatched (2017)

Read More at VV — Know the Cast: ‘Champagne Problems’

Little Brother Cast: Sherry Cola as Mia

Character Profile: Rudd’s assistant. She responds to e-mails from fans. Mia admits to catfishing Marcel.

Cola’s Resume: Alice Kwan in Good Trouble (2019-24), Lolo in Joy Ride – The Trip (2023), Alice in Shortcomings (2023), Ashley in Nobody Wants This (2024-), Maya in Shrinking (2025)

Read More at VV — Know the Cast: ‘Nouvelle Vague’

Little Brother Cast: Ego Nwodim as Lenora

Character Profile: A reality TV executive. She shapes Rudd’s character arc with colleagues. Lenora integrates Marcel into her show.

Nwodim’s Resume: Saturday Night Live Cast Member (2018-25), Emily in Spin Me Round (2022), Edie in Good Burger 2 (2023), Claire in Players (2024), Kate Woodson in Not Suitable for Work (2026)

Read More at VV — Know the Cast: ‘Happy Gilmore 2’

The Little Brother cast also includes:

• Caleb Hearon as Olly
• Bryce Gheisar as Cory Landy
• Pilot Bunch as Shane Landy
• Ben Ahlers as Kieran Francis
• Sophia Bunnell as Ashley
• Christina Catechis as Nurse Sonj
• Brett Azar as Yayir
• Briane Keane as Renaissance Recovery Counselor
• Tony Torn as Keith
• Dani Deetté as Medic Jones

Q.V. Hough (@QVHough) is Vague Visages’ founding editor.