The Opus cast features Ayo Edebiri, John Malkovich and Juliette Lewis. This info article contains minor spoilers and character details for Mark Anthony Green’s 2025 movie on HBO Max. Check out more cast guides in Vague Visages’ Know the Cast category.

Opus centers on a female journalist and a reclusive musician. When a pop star named Alfred Moretti reappears after a 30-year hiatus, he invites a select group of people to a listening party in Utah. The narrative follows a writer’s attempts to understand the focal musician’s motivations and bizarre behavior. Here’s every actor and character in Opus.

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Opus Cast: Ayo Edebiri as Ariel Ecton

Character Profile: A journalist. She gets invited to Alfred’s listening party. Ariel realizes that her subject is part of a cult.

Edebiri’s Resume: Missy Foreman-Greenwald in Big Mouth (2020-), Hattie in Dickinson (2021), Stand Up in How It Ends (2021), Sydney Adamu in The Bear (2022-), Stella in Hello, Goodbye and Everything in Between (2022)

Read More at VV — Know the Cast: ‘Caddo Lake’

Opus Cast: John Malkovich as Alfred Moretti

Character Profile: A reclusive musician who was popular in the 80s and 90s. He reappears after 30 years to release his 18th studio album. Alfred is part of cult known as the “Levelists” who hide their true motivations.

Malkovich’s Resume: Vicomte de Valmont in Dangerous Liaisons (1988), Mitch Leary in In the Line of Fire (1993), Teddy KGB in Rounders (1998), John Horatio Malkovich in Being John Malkovich (1999), Osborne Cox in Burn After Reading (2008)

Read More at VV — Know the Cast: ‘A Different Man’

Opus Cast: Juliette Lewis as Clara Armstrong

Character Profile: A talk show host. She is a pop culture sex symbol who attends a listening party. Clara made jokes about Alfred’s bald head in the past.

Lewis’ Resume: Danielle Bowden in Cape Fear (1991), Mallory Knox in Natural Born Killers (1994), Kate Fuller in From Dusk Til Dawn (1996), Andrea Cornell in Secrets and Lies (2015-16), Natalie in Yellowjackets (2021-23)

Read More at VV — Know the Cast: ‘Heretic’

Opus Cast: Murray Bartlett as Stan Sullivan

Character Profile: Ariel’s editor. He gets shot by an arrow before getting attacked by Levelists. Stan referred to one of Alfred’s albums as “overrated” in the past.

Bartlett’s Resume: Troy in August (2011), Dom Basaluzzo in Looking (2014-15), in Michael “Mouse” Tolliver in Tales of the City (2019), Armond in The White Lotus (2021), Brian in Nine Perfect Strangers (2025)

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The Opus cast also includes:

• Melissa Chambers as Bianca Tyson
• Tony Hale as Soledad Yusef
• Stephanie Suganami as Emily Katz
• Mark Sivertsen as Bill Lotto
• Amber Midthunder as Belle
• Tatanka Means as Najee
• Aspen Martinez as Maude
• Peter Diseth as Jorg
• Tamera Tomakili as Rachel Malick
• Rose Marley Meizlesh as Levelist #1

Q.V. Hough (@QVHough) is Vague Visages’ founding editor.