The Painkiller cast features Uzo Aduba, Matthew Broderick and Taylor Kitsch. This info article contains minor spoilers and character details for Micah Fitzerman-Blue and Noah Harpster’s 2023 Netflix miniseries. Check out more streaming guides in Vague Visages’ Know the Cast section.

Painkiller explores the OxyContin epidemic in America. As Edie Flowers investigates medical malpractice, she learns about a larger issue. The narrative follows the main protagonist as she targets Purdue Pharma. Here’s every actor and character in Painkiller, an adaptation of Patrick Radden Keefe’s 2017 article “The Family That Built an Empire of Pain” and Barry Meier’s 2018 book Pain Killer: An Empire of Deceit and the Origin of America’s Opioid Epidemic.

Read More at VV — Know the Cast & Characters: ‘Heart of Stone’

Painkiller Cast: Uzo Aduba as Edie Flowers

Character Profile: A federal investigator. She researches the rise of OxyContin in America. Edie investigates Purdue Pharma while sorting through personal issues.

Aduba’s Resume: Suzanne “Crazy Eyes” Warren in Orange Is the New Black (2013-19), Queen Novo in My Little Pony: The Movie (2017), Shirley Chisholm in Mrs. America (2020), Dr. Brooke Taylor in In Treatment (2021), Alisha Hawthorne in Lightyear (2022)

Read More at VV — Know the Cast & Characters: ‘Paradise’

Painkiller Cast: Matthew Broderick as Richard Sackler

Character Profile: The head of Purdue Pharma. He orchestrates the OxyContin epidemic in America. Richard vows to destroy the competition.

Broderick’s Resume: David in WarGames (1983), Ferris Bueller in Ferris Bueller’s Day Off (1986), Steven M. Kovacs in The Cable Guy (1996), Leo Bloom in The Producers (2005), Michael Burr in Daybreak (2019)

Read More at VV — Know the Cast & Characters: ‘Happiness for Beginners’

Painkiller Cast: Taylor Kitsch as Glen Kryger

Character Profile: A Kryger Tires employee. He becomes addicted to OxyContin after a back injury. Glen desperately tries to find a solution for his pain.

Kitsch’s Resume: Tim Riggins in Friday Night Lights (2006-11), Remy LeBeau in X-Men Origins: Wolverine (2009), John Carter in John Carter (2012), David Koresh in Waco (2018), Ben Edwards in The Terminal List (2022)

Read More at VV — Know the Cast & Characters: ‘Seasons’

Painkiller Cast: Dina Shihabi as Britt Hufford

Character Profile: A Purdue Pharma sales manager. She recruits young women. Britt lives a reckless lifestyle while using OxyContin.

Shihabi’s Resume: Hanin in Tom Clancy’s Jack Ryan (2018), Neda Kazemi in Daredevil (2018), Nour in Ramy (2019), Dig 301 in Altered Carbon (2020), Dina Shihabi as Lena Asayran in Ghosts of Beirut (2023)

Read More at VV — Know the Cast & Characters: ‘They Cloned Tyrone’

Painkiller Cast: West Duchovny as Shannon Schaeffer

Character Profile: A Purdue Pharma employee. She learns about sales strategies from Britt. Shannon turns on Purdue Pharma after trying OxyContin.

Duchovny’s Resume: Maddy in The X-Files (2018), Whitley in The Magicians (2019), Paige in Vegas High (2020), Cream in A Mouthful of Air (2021), Alison Thomas in Saint X (2023)

Read More at VV — Know the Cast & Characters: ‘Survival of the Thickest’

Painkiller Cast: Clark Gregg as Arthur Sackler

Character Profile: A Purdue Pharma executive. He is a psychiatrist who promotes a “lobotomy in a bottle.” Arthur believes that marketing is the “future of pills.”

Gregg’s Resume: Richard Campbell in The New Adventures of Old Christine (2006-10), Lord High Charlie in Choke (2008), Agent Phil Coulson in the MCU (2012-), Gerald in Labor Day (2013), John in Moxie (2021)

Read More at VV — Know the Cast & Characters: ‘The Out-Laws’

Painkiller Cast: Jack Mulhern as Tyler Kryger

Character Profile: Glen’s step-son. He works at Kryger Tires. Tyler becomes interested in OxyContin.

Mulhern’s Resume: Grizz in The Society (2019), Teddy in Wu-Tang: An American Saga (2019), Bobby in Odd Man Rush (2020), Dylan Hinchey in Mare of Easttown (2021), Nick in Unconformity (2022)

Read More at VV — Know the Cast & Characters: ‘Nimona’

The Painkiller cast also includes:

• John Rothman as Mortimer Sackler
• Sam Anderson as Raymond Sackler
• Ana Cruz Kayne as Brianna Ortiz
• Brian Markinson as Howard Udell
• Carolina Bartczak as Lily Kryger
• Ron Lea as Bill Havens
• David Tompa a Conference Room Lawyer
• Noah Harpster as Dr. Curtis Wright
• John Ales as Dr. Gregory Fitzgibbons
• Johnny Sneed as Dr. Tim Cooper
• Tyler Ritter as John Brownlee
• Matt Baram as Dr. Robert Kaiko
• Cody Porter as Dr. Paul Goldenheim
• John Murphy as Michael Friedman
• Darrin Baker as Dr. Hartman

Q.V. Hough (@QVHough) is Vague Visages’ founding editor.