The Twisted Tale of Amanda Knox cast features Grace Van Patten, Sharon Horgan and Francesco Acquaroli. This info article contains minor spoilers and character details for K.J. Steinberg’s 2025 Hulu miniseries. Check out more cast guides in Vague Visages’ Know the Cast category.

The Twisted Tale of Amanda Knox centers on an American college student who studies abroad in Italy. When the titular character becomes the central figure in an Italian homicide investigation, she struggles to communicate effectively with local authorities. The narrative follows Amanda as she tries to clear her name. Here’s every actor and character in The Twisted Tale of Amanda Knox, an adaptation of Amanda Knox’s 2013 book Waiting to Be Heard: A Memoir.

Read More at VV — Know the Cast & Characters: ‘Tell Me Lies’

The Twisted Tale of Amanda Knox Cast: Grace Van Patten as Amanda Knox

Character Profile: An American college student from Seattle, Washington. She narrates about how she likes to live in her imagination. Amanda studies abroad in Perugia, Italy and gets accused of murder.

Van Patten’s Resume: Eliza in The Meyerowitz Stories (2017), Balloon Girl in Under the Silver Lake (2018), Ana in Mayday (2021), Zoe Marconi in Nine Perfect Strangers (2021), Lucy Albright in Tell Me Lies (2022-)

Read More at VV — Know the Cast: ‘Paradise’

The Twisted Tale of Amanda Knox Cast: Sharon Horgan as Edda Mellas

Character Profile: Amanda’s mother. She travels to Italy to support her daughter during a murder investigation. Edda struggles to communicate with Italian authorities.

Horgan’s Resume: Donna in Pulling (2006-09), Sharon Morris in Catastrophe (2015-19), Sarah in Game Night (2018), Queen Dagmar in Disenchantment (2018-23), Eva Garvey in Bad Sisters (2022-)

Read More at VV — Know the Cast: ‘Under the Bridge’

The Twisted Tale of Amanda Knox Cast: Francesco Acquaroli as Giuliano Mignini

Character Profile: An Italian magistrate who tries to “make sense of the senseless.” He firmly believes that Amanda is guilty of murder. Giuliano narrates about receiving divine guidance.

Acquaroli’s Resume: Vinicio Meconi in Diaz — Don’t Clean Up This Blood (2012), Sebastiano Carucci/Sebastiano Cecchetti in Rocco Schiavone: Ice Cold Murders (2016-25), Nicola in Sole cuore amore (2016), Samurai in Suburra: Blood on Rome (2017-20), Proprietario Videolottery in Dogman (2018)

Read More at VV — Know the Cast: ‘The Veil’

The Twisted Tale of Amanda Knox Cast: Giuseppe De Domenico as Raffaele Sollecito

Character Profile: Amanda’s boyfriend. He gets arrested for conspiring in a murder. Raffaele betrays Amanda by not confirming her alibi.

De Domenico’s Resume: Giovanni in #Goldfish (2018), Stefano La Piana in ZeroZeroZero (2019-20), Rocco Cosentino in Bang Bang Baby (2022), Pietro Riso in Vermiglio (2024), Rocky in Last to Brake (2024)

Read More at VV — Know the Cast: ‘Black Cake’

The Twisted Tale of Amanda Knox Cast: John Hoogenakker as Curt Knox

Character Profile: Amanda’s father. He favors posed pictures over spontaneous pictures. Curt appears in flashback scenes during the first two episodes.

Hoogenakker’s Resume: Gordon Sirica in The Girlfriend Experience (2016), Matice in Tom Clancy’s Jack Ryan (2018-19), Carl Wilkes in Castle Rock (2019), Randy Ramseyer in Dopesick (2021), Clive Doyle in Waco: The Aftermath (2023)

Read More at VV — Know the Cast: ‘Good American Family’

The Twisted Tale of Amanda Knox Cast: Roberta Mattei as Monica Napoleoni

Character Profile: An Italian detective. She suspects Amanda of staging a break-in to cover up a homicide. Monica works closely with Giuliano during their investigation.

Mattei’s Resume: Rhada Ragalan in Sweet India (2006), Annarella in Italian Race (2016), Deputy Chief Mattei in Solo (2018), La Vergine in Zero (2021), Katia la “Picciridduna” in Anna (2021)

Read More at VV — Know the Cast: ‘We Were the Lucky Ones’

The Twisted Tale of Amanda Knox cast also includes:

• Joe Lanza as Chris Mellas
• Alfredo Pea as Don Saulo Scarabattoli
• Anna Van Patten as Deanna Knox
• Corinna Bennati Lo Castro as Ginevra Ferrari
• Rebecca Wisocky as Cecilia
• Crosby Fitzgerald as Madison
• Antonio Rampino as Francesco Sollecito
• Alessandro Garbin as Marco Zaroli
• Giuseppe Lo Piccolo as Edoardo Leone
• Evelyn Famà as Lucrezia Ippolito
• Filippo Brogi as Giacomo Silenzi
• Andy Nloga as Riccardo Luciani
• Francesca Turrini as Nadia Mancini
• Jared Canfield as Chris Robinson
• Sara Sedran as Kenzie Vidal

Q.V. Hough (@QVHough) is Vague Visages’ founding editor.